Nicotinamide riboside clóiríd Táirgeadh modh

The residue was transferred back to the 20 L reactor with 7.5 L of methanol. An ice bath was applied to the reactor to adjust the internal temperature to 3 degree . On the other hand, 3.75 L (3.75 mol) of 1M NaOCH3 dissolved in methanol was cooled to 3 degree , and then this solution was added to the reactor over 10 minutes. During the addition, the internal temperature was kept below 5 degree . After the addition was complete, the reaction mixture was stirred for 30 minutes, then 1.25 L (3.75 mol) of 3M HCl was added slowly, keeping the internal temperature below 5 degree . At the end of the addition of HCl, the pH=3. Solvent was removed under vacuum. (For convenience, the partially concentrated solution can be stored at 4 degree for up to 48h). After complete concentration, the residue can be stored at -20 degree for up to 18h. To remove residual methanol, the evaporation residue was dissolved in water and concentrated under vacuum (3x1 L). The residue was taken up in 5 L of water and the pH was adjusted to 4 with 2M NaOH(aq). Sodium chloride (NaCl) was added to the solution, and the mixture was stirred at room temperature until the NaCl was saturated, leaving about 5 g of undissolved NaCl. The saturated solution was extracted with tetrahydrofuran (THF, Chemicalbook 3x5L). The aqueous layer was monitored by 1H NMR to confirm that acetic acid had been removed after extraction was complete. The aqueous phase was adjusted to pH=6-7 with 2M NaOH(aq), then extracted with THF (4x5L). The aqueous layer was monitored by 1H NMR to confirm that residual nicotinamide was <5 mol% relative to nicotinamide riboside. The absence of triflate in the aqueous layer was also confirmed using 19FNMR. The aqueous layer was then concentrated under vacuum to remove 2.5 L of water. The residual suspension was diluted with 5 L of ethanol, filtered, and the salt precipitate was washed with 2.5 L of ethanol. The combined filtrate and washings were concentrated in vacuo to a thick oil. This was stirred with 1.5 L of methanol, the precipitate was filtered, and the solution was concentrated under vacuum. The residue was stirred with an additional 1.5 L of methanol, the precipitate was filtered and the solution concentrated in vacuo. The residue was stirred with a third 1.5 L portion of methanol, the precipitate was filtered and the solution concentrated in vacuo to give 385 g of an orange-red oil. The amount of residual methanol was confirmed to be 34 g by 1H NMR, and the crude product yield was 351 g (77%). THF extraction was used to remove most of the excess nicotinamide. 

Táimid a maith ar a dtugtar cógaisíochta idirmheánach monaróir in tSín % 2c le a iomlán táirgeadh córas agus cáilíocht bainistíochta córas % 2c agus an stóras tá leor stoc % 2c is féidir a a shipped ar an céanna lá de íocaíocht . Comhuaineach díolacháin in il cainéil ag baile agus thar lear % 2c ar líne agus as líne .

Bunaithe i 2011% 2c ár cuideachta is a ceannaireacht taighde-tiomáinte cógaisíochta cuideachta % 2c den chuid is mó mhonaraíonn cógaisíochta APIs agus idirmheánacha . Tarraingt go an maith caighdeán agus iomaíoch praghas % 2c againn a an- dea-cháil i tSín % 27s cógaisíochta ciorcail.
Más rud é tá a a táirge cáilíocht fadhb % 2c más rud é an tástáil is neamhcháilithe % 2c tá tar éis díolacháin ráthaíocht 2c we can return agus malartú an táirge saor in aisce de táille % 2c mar sin go tú tá aon imní .